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In any analysis, elimination of subjects from consideration is constrained by the data that are available.

With the development of sophisticated automated blood-cell analyzers, the proportion of blood-count samples that require a blood smear has steadily diminished and in many clinical settings is now Occasionally, a blood smear leads to a fortuitous diagnosis that can be very important to the patient.Hematological and iron-related analytes: reference data for persons aged 1 year and over: United States, 1988-94. This would obviously be true with the population designated "black," because it is well known that the genes of individuals classified as African American could be anywhere between 10% and 90% of European origin, with most of the remaining genome being of African origin.As pointed out earlier, differences in the degree of the European admixture could well account for the small differences in hemoglobin concentrations documented in the 2 data sets.As an example, the detection of features of unexpected hyposplenismmay suggest a congenital absence of the spleen, splenic atrophy, deposition of amyloid in the spleen, infiltration of neoplastic cells (e.g., in leukemia, lymphoma, or carcinoma) in the spleen, previous splenic infarction, or even a splenectomy of which the patient was unaware in each case putting the patient at risk for complications of hyposplenism.Conversely, the failure to observe expected hyposplenism in a blood smear from a patient who has undergone splenectomy for the treatment of autoimmune thrombocytopenic purpura may indicate that there is functioning residual splenic tissue, either from splenosis or from accessory spleens, that may be responsible for a relapse of the disease.

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